The Sidney Kimmel Comprehensive Cancer Center Johns Hopkins Medical Institutions – FAMRI Supported Research Publications

Famri Center of Excellence at The Sidney Kimmel Comprehensive Cancer Center Johns Hopkins Medical Institutions

FAMRI SUPPORTED RESEARCH – PUBLICATIONS

Aceituno P, Iglesias V, Erazo M, Droppelmann A, Orellana C, Navas-Acien A. [The work environment as a source of exposure to secondhand smoke: a study in workers of bars and restaurants of Santiago, Chile]. Rev Med Chil. 2010;138(12):1517-1523.

Aftab BT, Dobromilskaya I, Liu JO, Rudin CM. Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer. Cancer Res. 2011;71(21):6764-6772.

Agbenyikey W, Wellington E, Gyapong J, Travers MJ, Breysse PN, McCarty KM, Navas-Acien A. Secondhand tobacco smoke exposure in selected public places (PM2.5 and air nicotine) and non-smoking employees (hair nicotine) in Ghana. Tob Control. 2011;20(2):107-111.

Aggarwal NR, Chau E, Garibaldi BT, Mock JR, Sussan T, Rao K, Rao K, Menon AG, D’Alessio FR, Damarla M, Biswal S, King LS, Sidhaye VK. Aquaporin 5 regulates cigarette smoke induced emphysema by modulating barrier and immune properties of the epithelium. Tissue Barriers. 2013;1(4):e25248.

Aggarwal NR, D’Alessio FR, Eto Y, Chau E, Avalos C, Waickman AT, Garibaldi BT, Mock JR, Files DC, Sidhaye V, Polotsky VY, Powell J, Horton M, King LS. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol. 2013;48(5):635-646.

Aggarwal NR, King LS, D’Alessio FR. Diverse macrophage populations mediate acute lung inflammation and resolution. Am J Physiol Lung Cell Mol Physiol. 2014;306(8):L709-725.

Alani RM, Silverthorn CF, Orosz K. Tumor angiogenesis in mice and men. Cancer Biol Ther. 2004;3(6):498-500.

Alder JK, Barkauskas CE, Limjunyawong N, Stanley SE, Kembou F, Tuder RM, Hogan BL, Mitzner W, Armanios M. Telomere dysfunction causes alveolar stem cell failure. Proc Natl Acad Sci U S A. 2015;112(16):5099-5104.

Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, Tuder RM, Armanios M. Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med. 2011;184(8):904-912.

Apelberg BJ, Hepp LM, Avila-Tang E, Gundel L, Hammond SK, Hovell MF, Hyland A, Klepeis NE, Madsen CC, Navas-Acien A, Repace J, Samet JM, Breysse PN. Environmental monitoring of secondhand smoke exposure. Tob Control. 2013;22(3):147-155.

Apelberg BJ, Hepp LM, Avila-Tang E, Kim S, Madsen C, Ma J, Samet JM, Breysse PN. Racial differences in hair nicotine concentrations among smokers. Nicotine Tob Res. 2012;14(8):933-941.

Apostolou A, Garcia-Esquinas E, Fadrowski JJ, McLain P, Weaver VM, Navas-Acien A. Secondhand tobacco smoke: a source of lead exposure in US children and adolescents. Am J Public Health. 2012;102(4):714-722.

Armanios M. Telomerase and idiopathic pulmonary fibrosis. Mutat Res. 2012;730(1-2):52-58.

Armanios M. Telomeres and age-related disease: how telomere biology informs clinical paradigms. J Clin Invest. 2013;123(3):996-1002.

Armanios M. Reply: telomerase makes connections between pulmonary fibrosis and emphysema. Am J Respir Crit Care Med. 2014;189(6):754-755.

Armanios M, Blackburn EH. The telomere syndromes. Nat Rev Genet. 2012;13(10):693-704.

Armstrong CM, Meyers DJ, Imlay LS, Freel Meyers C, Odom AR. Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr). Antimicrob Agents Chemother. 2015;59(9):5511-5519.

Avery LB, Parsons TL, Meyers DJ, Hubbard WC. A highly sensitive ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) technique for quantitation of protein free and bound efavirenz (EFV) in human seminal and blood plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878(31):3217-3224.

Avila-Tang E, Al-Delaimy WK, Ashley DL, Benowitz N, Bernert JT, Kim S, Samet JM, Hecht SS. Assessing secondhand smoke using biological markers. Tob Control. 2013;22(3):164-171.

Avila-Tang E, Elf JL, Cummings KM, Fong GT, Hovell MF, Klein JD, McMillen R, Winickoff JP, Samet JM. Assessing secondhand smoke exposure with reported measures. Tob Control. 2013;22(3):156-163.

Avila-Tang E, Travers MJ, Navas-Acien A. Promoting smoke-free environments in Latin America: a comparison of methods to assess secondhand smoke exposure. Salud Publica Mex. 2010;52 Suppl 2:S138-148.

Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukherjee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschop MH, Boeke JD, Cole PA. Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science. 2010;330(6011):1689-1692.

Barnoya J, Arvizu M, Jones MR, Hernandez JC, Breysse PN, Navas-Acien A. Secondhand smoke exposure in bars and restaurants in Guatemala City: before and after smoking ban evaluation. Cancer Causes Control. 2011;22(1):151-156.

Barnoya J, Mendoza-Montano C, Navas-Acien A. Secondhand smoke exposure in public places in Guatemala: comparison with other Latin American countries. Cancer Epidemiol Biomarkers Prev. 2007;16(12):2730-2735.

Barnoya J, Navas-Acien A. Protecting the world from secondhand tobacco smoke exposure: where do we stand and where do we go from here? Nicotine Tob Res. 2013;15(4):789-804.

Bauer L, Ferla S, Head SA, Bhat S, Pasunooti KK, Shi WQ, Albulescu L, Liu JO, Brancale A, van Kuppeveld FJM, Strating J. Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP). Antiviral Res. 2018;156:55-63.

Becker PM, Tran TS, Delannoy MJ, He C, Shannon JM, McGrath-Morrow S. Semaphorin 3A contributes to distal pulmonary epithelial cell differentiation and lung morphogenesis. PLoS One. 2011;6(11):e27449.

Begum S, Brait M, Dasgupta S, Ostrow KL, Zahurak M, Carvalho AL, Califano JA, Goodman SN, Westra WH, Hoque MO, Sidransky D. An epigenetic marker panel for detection of lung cancer using cell-free serum DNA. Clin Cancer Res. 2011;17(13):4494-4503.

Benedict MD, Missmer SA, Ferguson KK, Vitonis AF, Cramer DW, Meeker JD. Secondhand tobacco smoke exposure is associated with prolactin but not thyroid stimulating hormone among nonsmoking women seeking in vitro fertilization. Environ Toxicol Pharmacol. 2012;34(3):761-767.

Benedict MD, Missmer SA, Vahratian A, Berry KF, Vitonis AF, Cramer DW, Meeker JD. Secondhand tobacco smoke exposure is associated with increased risk of failed implantation and reduced IVF success. Hum Reprod. 2011;26(9):2525-2531.

Bhan S, Negi SS, Shao C, Glazer CA, Chuang A, Gaykalova DA, Sun W, Sidransky D, Ha PK, Califano JA. BORIS binding to the promoters of cancer testis antigens, MAGEA2, MAGEA3, and MAGEA4, is associated with their transcriptional activation in lung cancer. Clin Cancer Res. 2011;17(13):4267-4276.

Bhat S, Hwang Y, Gibson MD, Morgan MT, Taverna SD, Zhao Y, Wolberger C, Poirier MG, Cole PA. Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action. J Am Chem Soc. 2018;140(30):9478-9485.

Bhat S, Shim JS, Zhang F, Chong CR, Liu JO. Substituted oxines inhibit endothelial cell proliferation and angiogenesis. Org Biomol Chem. 2012;10(15):2979-2992.

Bilal U, Beltran P, Fernandez E, Navas-Acien A, Bolumar F, Franco M. Gender equality and smoking: a theory-driven approach to smoking gender differences in Spain. Tob Control. 2016;25(3):295-300.

Bilal U, Fernandez E, Beltran P, Navas-Acien A, Bolumar F, Franco M. Validation of a method for reconstructing historical rates of smoking prevalence. Am J Epidemiol. 2014;179(1):15-19.

Bishop JA, Ma XJ, Wang H, Luo Y, Illei PB, Begum S, Taube JM, Koch WM, Westra WH. Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization method. Am J Surg Pathol. 2012;36(12):1874-1882.

Bisht S, Khan MA, Bekhit M, Bai H, Cornish T, Mizuma M, Rudek MA, Zhao M, Maitra A, Ray B, Lahiri D, Maitra A, Anders RA. A polymeric nanoparticle formulation of curcumin (NanoCurc) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation. Lab Invest. 2011;91(9):1383-1395.

Bisht S, Mizuma M, Feldmann G, Ottenhof NA, Hong SM, Pramanik D, Chenna V, Karikari C, Sharma R, Goggins MG, Rudek MA, Ravi R, Maitra A, Maitra A. Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol Cancer Ther. 2010;9(8):2255-2264.

Bivalacqua TJ, Sussan TE, Gebska MA, Strong TD, Berkowitz DE, Biswal S, Burnett AL, Champion HC. Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunction. J Urol. 2009;181(2):899-906.

Blake DJ, Singh A, Kombairaju P, Malhotra D, Mariani TJ, Tuder RM, Gabrielson E, Biswal S. Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. Am J Respir Cell Mol Biol. 2010;42(5):524-536.

Blanco-Marquizo A, Goja B, Peruga A, Jones MR, Yuan J, Samet JM, Breysse PN, Navas-Acien A. Reduction of secondhand tobacco smoke in public places following national smoke-free legislation in Uruguay. Tob Control. 2010;19(3):231-234.

Boija A, Mahat DB, Zare A, Holmqvist PH, Philip P, Meyers DJ, Cole PA, Lis JT, Stenberg P, Mannervik M. CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II. Mol Cell. 2017;68(3):491-503 e495.

Bowers EM, Yan G, Mukherjee C, Orry A, Wang L, Holbert MA, Crump NT, Hazzalin CA, Liszczak G, Yuan H, Larocca C, Saldanha SA, Abagyan R, Sun Y, Meyers DJ, Marmorstein R, Mahadevan LC, Alani RM, Cole PA. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010;17(5):471-482.

Brait M, Loyo M, Rosenbaum E, Ostrow KL, Markova A, Papagerakis S, Zahurak M, Goodman SM, Zeiger M, Sidransky D, Umbricht CB, Hoque MO. Correlation between BRAF mutation and promoter methylation of TIMP3, RARbeta2 and RASSF1A in thyroid cancer. Epigenetics. 2012;7(7):710-719.

Brait M, Maldonado L, Begum S, Loyo M, Wehle D, Tavora FF, Looijenga LH, Kowalski J, Zhang Z, Rosenbaum E, Halachmi S, Netto GJ, Hoque MO. DNA methylation profiles delineate epigenetic heterogeneity in seminoma and non-seminoma. Br J Cancer. 2012;106(2):414-423.

Brait M, Maldonado L, Noordhuis MG, Begum S, Loyo M, Poeta ML, Barbosa A, Fazio VM, Angioli R, Rabitti C, Marchionni L, de Graeff P, van der Zee AG, Wisman GB, Sidransky D, Hoque MO. Association of promoter methylation of VGF and PGP9.5 with ovarian cancer progression. PLoS One. 2013;8(9):e70878.

Brait M, Munari E, LeBron C, Noordhuis MG, Begum S, Michailidi C, Gonzalez-Roibon N, Maldonado L, Sen T, Guerrero-Preston R, Cope L, Parrella P, Fazio VM, Ha PK, Netto GJ, Sidransky D, Hoque MO. Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma. Cell Cycle. 2013;12(7):1058-1070.

Breysse PN, Navas-Acien A. The smoking gun: working to eliminate tobacco smoke exposure. J Expo Sci Environ Epidemiol. 2010;20(5):397-398.

Burns TF, Dobromilskaya I, Murphy SC, Gajula RP, Thiyagarajan S, Chatley SN, Aziz K, Cho YJ, Tran PT, Rudin CM. Inhibition of TWIST1 leads to activation of oncogene-induced senescence in oncogene-driven non-small cell lung cancer. Mol Cancer Res. 2013;11(4):329-338.

Butz AM, Breysse P, Rand C, Curtin-Brosnan J, Eggleston P, Diette GB, Williams D, Bernert JT, Matsui EC. Household smoking behavior: effects on indoor air quality and health of urban children with asthma. Matern Child Health J. 2011;15(4):460-468.

Butz AM, Matsui EC, Breysse P, Curtin-Brosnan J, Eggleston P, Diette G, Williams D, Yuan J, Bernert JT, Rand C. A randomized trial of air cleaners and a health coach to improve indoor air quality for inner-city children with asthma and secondhand smoke exposure. Arch Pediatr Adolesc Med. 2011;165(8):741-748.

Byron MJ, Suhadi DR, Hepp LM, Avila-Tang E, Yang J, Asiani G, Rubaeah., Tamplin SA, Bam TS, Cohen JE. Secondhand tobacco smoke in public venues in three Indonesian cities. Med J Indonesia. 2013;22(4):232-237.

Cerchietti LC, Hatzi K, Caldas-Lopes E, Yang SN, Figueroa ME, Morin RD, Hirst M, Mendez L, Shaknovich R, Cole PA, Bhalla K, Gascoyne RD, Marra M, Chiosis G, Melnick A. BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy. J Clin Invest. 2010;120(12):4569-4582.

Chau E, Galloway JF, Nelson A, Breysse PN, Wirtz D, Searson PC, Sidhaye VK. Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro. Nanotoxicology. 2013;7(6):1143-1151.

Chen X, Xie S, Bhat S, Kumar N, Shapiro TA, Liu JO. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol. 2009;16(2):193-202.

Chen Z, Cole PA. Synthetic approaches to protein phosphorylation. Curr Opin Chem Biol. 2015;28:115-122.

Chenna V, Hu C, Pramanik D, Aftab BT, Karikari C, Campbell NR, Hong SM, Zhao M, Rudek MA, Khan SR, Rudin CM, Maitra A. A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists. Mol Cancer Ther. 2012;11(1):165-173.

Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, Powell JD, Cole PA. An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. J Am Chem Soc. 2014;136(9):3370-3373.

Choi SM, Kim Y, Shim JS, Park JT, Wang RH, Leach SD, Liu JO, Deng C, Ye Z, Jang YY. Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells. Hepatology. 2013;57(6):2458-2468.

Chong CR, Xu J, Lu J, Bhat S, Sullivan DJ, Jr., Liu JO. Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol. 2007;2(4):263-270.

Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. 2018;174(4):897-907 e814.

Chu SH, Feng DF, Ma YB, Zhu ZA, Zhang H, Qiu JH. Stabilization of hepatocyte growth factor mRNA by hypoxia-inducible factor 1. Mol Biol Rep. 2009;36(7):1967-1975.

Chun YS, Bisht S, Chenna V, Pramanik D, Yoshida T, Hong SM, de Wilde RF, Zhang Z, Huso DL, Zhao M, Rudek MA, Stearns V, Maitra A, Sukumar S. Intraductal administration of a polymeric nanoparticle formulation of curcumin (NanoCurc) significantly attenuates incidence of mammary tumors in a rodent chemical carcinogenesis model: Implications for breast cancer chemoprevention in at-risk populations. Carcinogenesis. 2012;33(11):2242-2249.

Chung CH, Dignam JJ, Hammond ME, Klimowicz AC, Petrillo SK, Magliocco A, Jordan R, Trotti A, Spencer S, Cooper JS, Le QT, Ang KK. Glioma-associated oncogene family zinc finger 1 expression and metastasis in patients with head and neck squamous cell carcinoma treated with radiation therapy (RTOG 9003). J Clin Oncol. 2011;29(10):1326-1334.

Cleveland TEt, McCabe JM, Leahy DJ. Detergent-solubilized Patched purified from Sf9 cells fails to interact strongly with cognate Hedgehog or Ihog homologs. Protein Expr Purif. 2014;104:92-102.

Cole PA. Chemical probes for histone-modifying enzymes. Nat Chem Biol. 2008;4(10):590-597.

Collaco JM, Aherrera AD, McGrath-Morrow SA. The influence of gender on respiratory outcomes in children with bronchopulmonary dysplasia during the first 3 years of life. Pediatr Pulmonol. 2017;52(2):217-224.

Collaco JM, McGready J, Green DM, Naughton KM, Watson CP, Shields T, Bell SC, Wainwright CE, Group AS, Cutting GR. Effect of temperature on cystic fibrosis lung disease and infections: a replicated cohort study. PLoS One. 2011;6(11):e27784.

Collins SL, Black KE, Chan-Li Y, Ahn YH, Cole PA, Powell JD, Horton MR. Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor. Am J Respir Cell Mol Biol. 2011;45(4):675-683.

Crump NT, Hazzalin CA, Bowers EM, Alani RM, Cole PA, Mahadevan LC. Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A. 2011;108(19):7814-7819.

Cummings SD, Ryu B, Samuels MA, Yu X, Meeker AK, Healey MA, Alani RM. Id1 delays senescence of primary human melanocytes. Mol Carcinog. 2008;47(9):653-659.

Dancy BM, Cole PA. Protein lysine acetylation by p300/CBP. Chem Rev. 2015;115(6):2419-2452.

Dancy BM, Crump NT, Peterson DJ, Mukherjee C, Bowers EM, Ahn YH, Yoshida M, Zhang J, Mahadevan LC, Meyers DJ, Boeke JD, Cole PA. Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Chembiochem. 2012;13(14):2113-2121.

Daniel VC, Marchionni L, Hierman JS, Rhodes JT, Devereux WL, Rudin CM, Yung R, Parmigiani G, Dorsch M, Peacock CD, Watkins DN. A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro. Cancer Res. 2009;69(8):3364-3373.

Dasgupta P, Rizwani W, Pillai S, Davis R, Banerjee S, Hug K, Lloyd M, Coppola D, Haura E, Chellappan SP. ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors. J Natl Cancer Inst. 2011;103(4):317-333.

Datan E, Minn I, Xu P, He QL, Ahn HH, Yu B, Pomper MG, Liu JO. A Glucose-Triptolide Conjugate Selectively Targets Cancer Cells under Hypoxia. iScience. 2020;23(9):101536.

Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol. 2011;12(4):295-303.

DeLuca AM, Srinivas A, Alani RM. BRAF kinase in melanoma development and progression. Expert Rev Mol Med. 2008;10:e6.

Deshpande A, Kudtarkar P, Dhaware D, Chowgule R. Study of secondhand smoke levels pre and post implementation of the comprehensive smoking ban in Mumbai. Indian J Community Med. 2010;35(3):409-413.

Elf JL, Modi B, Stillman F, Dave P, Apelberg B. Tobacco sales and marketing within 100 yards of schools in Ahmedabad City, India. Public Health. 2013;127(5):442-448.

Ellis L, Shah P, Hammers H, Lehet K, Sotomayor P, Azabdaftari G, Seshadri M, Pili R. Vascular disruption in combination with mTOR inhibition in renal cell carcinoma. Mol Cancer Ther. 2012;11(2):383-392.

Erazo M, Iglesias V, Droppelmann A, Acuna M, Peruga A, Breysse PN, Navas-Acien A. Secondhand tobacco smoke in bars and restaurants in Santiago, Chile: evaluation of partial smoking ban legislation in public places. Tob Control. 2010;19(6):469-474.

Fatokun AA, Liu JO, Dawson VL, Dawson TM. Identification through high-throughput screening of 4′-methoxyflavone and 3′,4′-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos. Br J Pharmacol. 2013;169(6):1263-1278.

Fertig EJ, Markovic A, Danilova LV, Gaykalova DA, Cope L, Chung CH, Ochs MF, Califano JA. Preferential activation of the hedgehog pathway by epigenetic modulations in HPV negative HNSCC identified with meta-pathway analysis. PLoS One. 2013;8(11):e78127.

Francetic T, Le May M, Hamed M, Mach H, Meyers D, Cole PA, Chen J, Li Q. Regulation of Myf5 Early Enhancer by Histone Acetyltransferase p300 during Stem Cell Differentiation. Mol Biol. 2012;1.

Fu C, van der Zwan A, Gerber S, Van Den Berg S, No E, Wang WC, Sheibani N, Carducci MA, Kachhap S, Hammers HJ. Screening assay for blood vessel maturation inhibitors. Biochem Biophys Res Commun. 2013;438(2):364-369.

Garcia-Esquinas E, Loeffler LF, Weaver VM, Fadrowski JJ, Navas-Acien A. Kidney function and tobacco smoke exposure in US adolescents. Pediatrics. 2013;131(5):e1415-1423.

Gardner EE, Connis N, Poirier JT, Cope L, Dobromilskaya I, Gallia GL, Rudin CM, Hann CL. Rapamycin rescues ABT-737 efficacy in small cell lung cancer. Cancer Res. 2014;74(10):2846-2856.

Giotopoulos G, Chan WI, Horton SJ, Ruau D, Gallipoli P, Fowler A, Crawley C, Papaemmanuil E, Campbell PJ, Gottgens B, Van Deursen JM, Cole PA, Huntly BJ. The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia. Oncogene. 2016;35(3):279-289.

Gluckman TJ, McLean RC, Schulman SP, Kickler TS, Shapiro EP, Conte JV, McNicholas KW, Segal JB, Rade JJ. Effects of aspirin responsiveness and platelet reactivity on early vein graft thrombosis after coronary artery bypass graft surgery. J Am Coll Cardiol. 2011;57(9):1069-1077.

Gonzalez-Gil A, Li TA, Porell RN, Fernandes SM, Tarbox HE, Lee HS, Aoki K, Tiemeyer M, Kim J, Schnaar RL. Isolation, identification, and characterization of the human airway ligand for the eosinophil and mast cell immunoinhibitory receptor Siglec-8. J Allergy Clin Immunol. 2021;147(4):1442-1452.

Gonzalez-Gil A, Porell RN, Fernandes SM, Wei Y, Yu H, Carroll DJ, McBride R, Paulson JC, Tiemeyer M, Aoki K, Bochner BS, Schnaar RL. Sialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways. Glycobiology. 2018;28(10):786-801.

Goodrich AC, Meyers DJ, Frueh DP. Molecular impact of covalent modifications on nonribosomal peptide synthetase carrier protein communication. J Biol Chem. 2017;292(24):10002-10013.

Govindarajan B, Shah A, Cohen C, Arnold RS, Schechner J, Chung J, Mercurio AM, Alani R, Ryu B, Fan CY, Cuezva JM, Martinez M, Arbiser JL. Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB. J Biol Chem. 2005;280(14):13936-13943.

Guidez F, Howell L, Isalan M, Cebrat M, Alani RM, Ivins S, Hormaeche I, McConnell MJ, Pierce S, Cole PA, Licht J, Zelent A. Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol Cell Biol. 2005;25(13):5552-5566.

Guo Z, Cheng Z, Wang J, Liu W, Peng H, Wang Y, Rao AVS, Li RJ, Ying X, Korangath P, Liberti MV, Li Y, Xie Y, Hong SY, Schiene-Fischer C, Fischer G, Locasale JW, Sukumar S, Zhu H, Liu JO. Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays. Angew Chem Int Ed Engl. 2019;58(48):17158-17162.

Guo Z, Hong SY, Wang J, Rehan S, Liu W, Peng H, Das M, Li W, Bhat S, Peiffer B, Ullman BR, Tse CM, Tarmakova Z, Schiene-Fischer C, Fischer G, Coe I, Paavilainen VO, Sun Z, Liu JO. Rapamycin-inspired macrocycles with new target specificity. Nat Chem. 2019;11(3):254-263.

Hann CL, Daniel VC, Sugar EA, Dobromilskaya I, Murphy SC, Cope L, Lin X, Hierman JS, Wilburn DL, Watkins DN, Rudin CM. Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer. Cancer Res. 2008;68(7):2321-2328.

Hann CL, Rudin CM. Fast, hungry and unstable: finding the Achilles’ heel of small-cell lung cancer. Trends Mol Med. 2007;13(4):150-157.

Hann CL, Rudin CM. Management of small-cell lung cancer: incremental changes but hope for the future. Oncology (Williston Park). 2008;22(13):1486-1492.

Harutyunyan A, Movsisyan N, Petrosyan V, Petrosyan D, Stillman F. Reducing children’s exposure to secondhand smoke at home: a randomized trial. Pediatrics. 2013;132(6):1071-1080.

Harvey CJ, Thimmulappa RK, Singh A, Blake DJ, Ling G, Wakabayashi N, Fujii J, Myers A, Biswal S. Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress. Free Radic Biol Med. 2009;46(4):443-453.

Hayward D, Cole PA. LSD1 Histone Demethylase Assays and Inhibition. Methods Enzymol. 2016;573:261-278.

He C, Cole P. Introduction: epigenetics. Chem Rev. 2015;115(6):2223-2224.

He QL, Minn I, Wang Q, Xu P, Head SA, Datan E, Yu B, Pomper MG, Liu JO. Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation. Angew Chem Int Ed Engl. 2016;55(39):12035-12039.

He R, Yu ZH, Zhang RY, Wu L, Gunawan AM, Lane BS, Shim JS, Zeng LF, He Y, Chen L, Wells CD, Liu JO, Zhang ZY. Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. ACS Med Chem Lett. 2015;6(7):782-786.

Head SA, Liu JO. Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling. J Vis Exp. 2016(115).

Head SA, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, Deng Z, Li RJ, Shim JS, Tan W, Hartung T, Zhang J, Zhao Y, Colombini M, Liu JO. Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells. Proc Natl Acad Sci U S A. 2015;112(52):E7276-7285.

Head SA, Shi WQ, Yang EJ, Nacev BA, Hong SY, Pasunooti KK, Li RJ, Shim JS, Liu JO. Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis. ACS Chem Biol. 2017;12(1):174-182.

Heikamp EB, Patel CH, Collins S, Waickman A, Oh MH, Sun IH, Illei P, Sharma A, Naray-Fejes-Toth A, Fejes-Toth G, Misra-Sen J, Horton MR, Powell JD. The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex. Nat Immunol. 2014;15(5):457-464.

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PRESENTATIONS AND ABSTRACTS

Avila-Tang E. Coalition-building for child and family health and tobacco control. Presented at the American Academy of Pediatrics, Pan American Health Organization, XVI Latin American Congress of Pediatrics, Cartagena de Indias, Colombia, Nov 14-18, 2012.

Avila-Tang E. Epidemiology of tobacco use and secondhand smoke exposure among-children. Presented at the 3rd Latin America and Caribbean Conference on Tobacco or Health. Lima, Peru, Oct 2011.

Avila-Tang E. How do we measure secondhand smoke? Presented at the 15th World Conference on Tobacco or Health, Singapore, Mar 2012.

Fu C, Gerber S, Van Den Berg S, Van Der Zwan A, Steenwinkel F, Kant H, Moriarty WF, Keizman D, Marchionni L, Netto GJ, Carducci MA, Kachhap S and Hammers H. Epithelial mesenchymal transition: a mechanism of resistance to VEGF pathway inhibition in genitourinary cancers [abstract]. American Association for Cancer Research. Chicago, IL, Mar 31-Apr 4, 2012.

Hammers H, Fu C, Gerber S, Van Den Berg S, van der Zwan A, Steenwinkel F, Moriarty W, Keizman D, Kachhap S, Carducci M. Epithelial-Mesenchymal-Transition: A mechanism of resistance to VEGF pathway inhibition in genitourinary cancers. [abstract] American Society of Clinical Oncology Conference. Chicago IL, Jun 1-5 2012.

Hammers H, Paesante S, Rudek M, Pili R. Combination of the VEGF receptor tyrosine kinase sunitinib and the mTOR inhibitor rapamycin leads to tumor regression in the RENCA model. Presented at the AACR Annual meeting. San Diego, CA, Apr 12-16, 2008.

Hammers HJ, Salumbides B, Shen L, Paesante S, Rudek M, Verheul HM, Pili R. From bedside to the bench: tumor microenvironment is responsible for the acquired resistance to tyrosine kinase inhibitors in renal cell carcinoma. Presented at the AACR Annual meeting. San Diego, CA, Apr 12-16, 2008.

Harutyunyan A, Movsisyan N, Petrosyan V, Petrosyan D, Hepp L, Avika-Tang E, Donaldson E, Stillman F. Developing a model for smoke-free universities. Presented at the European Conference on Tobacco or Health. Amsterdam, The Netherlands, Mar 28-30, 2011. 9. Harutyunyan A, Movsisyan NK, Petrosyan V, Petrosyan D. Reduced secondhand smoke exposure in homes, Armenia, 2010. Presented at the 5th European Public Health Conference. Malta, Nov 8-11, 2012.

Jones MR, Apelberg BJ, Samet JM, Navas- Acien A. Race/ethnicity, menthol cigarettes and biomarkers of tobacco use in US adults. Presented at the International Society for Environmental Epidemiology 24th Conference. Columbia, SC, Aug 26-30,2012.

Nieman C, Navas-Acien A, Lin S, Reh D. Physician inquiry of secondhand tobacco smoke exposure in chronic rhinosinusitis patients: a population-based case-control study. Presented at the American Laryngological, Rhinological and Otological Society. Scottsdale, AZ, Jan 10-12, 2013.

Onn A, Wrangle J, Siloni GH, Damianovich M, Cohen Y, Zadok O, Yarden R, PerelmanM, Amariglio N, Hooker C, Brock MV, Rechavi G, Rudin CM. Predicting recurrence in early stage, resected non-small cell lung cancer using mutational and methylation biomarkers [abstract]. 14th World Conference on Lung Cancer Proceedings J Thor Oncol 201;6:S1115.

Petrosyan D, Movsisyan N, Petrosyan V, Harutyunyan A, Hepp L, Avika-Tang E, Donaldson E, Stillman F. Smoke-free hospitals: Determinants of success. Presented at the European Conference on Tobacco or Health. Amsterdam, The Netherlands, Mar 28-30, 2011.

Stillman F, Movsisyan N, Petrosyan D, Harutyunyan A, Usmanova G, Andreeva T, Krstev S, Bakhturidze G. Symposium implementing smoke-free worksites in Central/ Eastern Europe and Central Asia. Presented at the European Conference on Tobacco or Health. Amsterdam, The Netherlands, Mar 28-30, 2011.

Wrangle JM, Juergens RA, Vendetti F, Coleman B, Sebree R, Rudek M, Herman J, Rudin CM, Brock MV. Biomarker development for a Phase II study of combination epigenetic therapy in advanced non-small cell lung cancer (NSCLC). Presented at the World Conference on Lung Cancer. Amsterdam, The Netherlands, Jul 3-7, 2011.

BOOK CHAPTERS, ETC.

Liu J, Shi W. Invention disclosure: “Itraconazole stereoisomers and use thereof”. 2012.

Liu J, Shim JS. Invention disclosure: “Nelfinavir as a Her2-positive breast cancer and a novel Hsp90 inhibitor”. 2010.

Liu, J, Sun Z, Peiffer BJ, Wang Y, Ahmadi AR, Guo Z, Peng H, Ahmad A. Invention disclosure: “Non-immunosuppressive FK506 analogs and use thereof”. 2018.

Liu, J, Xu J, Dang Y. Invention disclosure: “Lysosomal cholesterol trafficking pathway as a new target for inhibition of angiogenesis”. 2010.

Meyers C, Meyers D. Invention disclosure: “Hydroxamic acids targeting early stage isoprenoid biosynthesis in P. falciparum.” 2011.

Meyers, D. Invention Disclosure. Inhibitors of human cytomegalovirus; JHU reference C16649. 2021.

Poirer JT, Rudin CM. Invention disclosure: “Predictive biomarkers for SVV-001 permissivity and efficacy in human cancers”. 2010.

Semenza G, Le KA. Invention disclosure: “Identification of a class of drugs that blocks tumor growth by blocking the binding of HIF-l to DNA and method of use.” 2008.

Semenza G, Le KA. Invention disclosure: “Screen for inhibitors of HIF-1 dimerization”. 2008.