FAMRI Scientific Publications

Presented here is a compilation of 4,250 FAMRI-supported peer-reviewed publications (as of February 16, 2022). These publications stem from 570 grants awarded to more than 500 different investigators. The outcome of the discoveries is inspiring and sets the stage for prevention, early detection, treatment, and cures of tobacco-related diseases. The results in these publications have contributed to, and continue to contribute to, the overall betterment of public health. The charts below illustrate FAMRI scientific publications by topic and by keywords.

FAMRI Publications by Topic

FAMRI Publications by Keyword

Flight Attendant Medical Research Institute Publications and Presentations: 2002-2021

Publications and Presentations: 2021

Aguilera-Castrejon A, Oldak B, Shani T, Ghanem N, Itzkovich C, Slomovich S, Tarazi S, Bayerl J, Chugaeva V, Ayyash M, Ashouokhi S, Sheban D, Livnat N, Lasman L, Viukov S, Zerbib M, Addadi Y, Rais Y, Cheng S, Stelzer Y, Keren-Shaul H, Shlomo R, Massarwa R, Novershtern N, Maza I, Hanna JH. Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis. Nature. 2021;593(7857):119-124.

Bayerl J, Ayyash M, Shani T, Manor YS, Gafni O, Massarwa R, Kalma Y, Aguilera-Castrejon A, Zerbib M, Amir H, Sheban D, Geula S, Mor N, Weinberger L, Naveh Tassa S, Krupalnik V, Oldak B, Livnat N, Tarazi S, Tawil S, Wildschutz E, Ashouokhi S, Lasman L, Rotter V, Hanna S, Ben-Yosef D, Novershtern N, Viukov S, Hanna JH. Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell Stem Cell. 2021.

Challa AK, Stanford D, Allen A, Rasmussen L, Amanor FK, Raju SV. Validation of gene editing efficiency with CRISPR-Cas9 system directly in rat zygotes using electroporation mediated delivery and embryo culture. MethodsX. 2021;8:101419.

Che P, Wang M, Larson-Casey JL, Hu RH, Cheng Y, El Hamdaoui M, Zhao XK, Grytz R, Brent Carter A, Ding Q. A novel tree shrew model of pulmonary fibrosis. Lab Invest. 2021;101(1):116-124.

Che P, Yu L, Friedman GK, Wang M, Ke X, Wang H, Zhang W, Nabors B, Ding Q, Han X. Integrin alphavbeta3 Engagement Regulates Glucose Metabolism and Migration through Focal Adhesion Kinase (FAK) and Protein Arginine Methyltransferase 5 (PRMT5) in Glioblastoma Cells. Cancers (Basel). 2021;13(5).

Chen D, Gregory AD, Li X, Wei J, Burton CL, Gibson G, Scott SJ, St Croix CM, Zhang Y, Shapiro SD. RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease. JCI Insight. 2021;6(12).

Choi EJ, Wu W, Cong X, Zhang K, Luo J, Ye S, Wang P, Suresh A, Ullah UM, Zhou J, Bao X. Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections. Viruses. 2021;13(6).

Elgamal Z, Singh P, Geraghty P. The Upper Airway Microbiota, Environmental Exposures, Inflammation, and Disease. Medicina (Kaunas). 2021;57(8).


Gill AS, Pulsipher A, Sumsion JS, Oakley GM, Leclair LW, Howe H, Orlandi RR, Alt JA. Transcriptional Changes in Chronic Rhinosinusitis with Asthma Favor a Type 2 Molecular Endotype Independent of Polyp Status. J Asthma Allergy. 2021;14:405-413.

Gonzalez-Gil A, Li TA, Porell RN, Fernandes SM, Tarbox HE, Lee HS, Aoki K, Tiemeyer M, Kim J, Schnaar RL. Isolation, identification, and characterization of the human airway ligand for the eosinophil and mast cell immunoinhibitory receptor Siglec-8. J Allergy Clin Immunol. 2021;147(4):1442-1452.

Kim MD, Baumlin N, Dennis JS, Yoshida M, Kis A, Aguiar C, Schmid A, Mendes E, Salathe M. Losartan reduces cigarette smoke-induced airway inflammation and mucus hypersecretion. ERJ Open Res. 2021;7(1).

Klein JD, Chamberlin ME, Kress EA, Geraci MW, Rosenblatt S, Boykan R, Jenssen B, Rosenblatt SM, Milberger S, Adams WG, Goldstein AO, Rigotti NA, Hovell MF, Holm AL, Vandivier RW, Croxton TL, Young PL, Blissard L, Jewell K, Richardson L, Ostrow J, Resnick EA. Asking the Right Questions About Secondhand Smoke. Nicotine Tob Res. 2021;23(1):57-62.

Klein JD, Resnick EA, Chamberlin ME, Kress EA. Second-hand smoke surveillance and COVID-19: a missed opportunity. Tob Control. 2021.

Lee HS, Gonzalez-Gil A, Drake V, Li TA, Schnaar RL, Kim J. Induction of the endogenous sialoglycan ligand for eosinophil death receptor Siglec-8 in chronic rhinosinusitis with hyperplastic nasal polyposis. Glycobiology. 2021.

Mitsunaga S, Shioda K, Hanna JH, Isselbacher KJ, Shioda T. Production and Analysis of Human Primordial Germ Cell-Like Cells. Methods Mol Biol. 2021;2195:125-145.

Nouws J, Wan F, Finnemore E, Roque W, Kim SJ, Bazan I, Li CX, Skold CM, Dai Q, Yan X, Chioccioli M, Neumeister V, Britto CJ, Sweasy J, Bindra R, Wheelock AM, Gomez JL, Kaminski N, Lee PJ, Sauler M. MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. JCI Insight. 2021;6(2).

Ren J, Wu W, Zhang K, Choi EJ, Wang P, Ivanciuc T, Peniche A, Qian Y, Garofalo RP, Zhou J, Bao X. Exchange Protein Directly Activated by cAMP 2 Enhances Respiratory Syncytial Virus-Induced Pulmonary Disease in Mice. Front Immunol. 2021;12:757758.

Rose BJ, Weyand JA, Liu B, Smith JF, Perez BR, Clark JC, Goodman M, Hirschi Budge KM, Eggett DL, Arroyo JA, Reynolds PR, Kooyman DL. Exposure to second-hand cigarette smoke exacerbates the progression of osteoarthritis in a surgical induced murine model. Histol Histopathol. 2021;36(3):347-353.

Singh DP, Begum R, Kaur G, Bagam P, Kambiranda D, Singh R, Batra S. E-cig vapor condensate alters proteome and lipid profiles of membrane rafts: impact on inflammatory responses in A549 cells. Cell Biol Toxicol. 2021.

Summers ME, Richmond BW, Kropski JA, Majka SA, Bastarache JA, Hatzopoulos AK, Bylund J, Ghosh M, Petrache I, Foronjy RF, Geraghty P, Majka SM. Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function. Am J Physiol Cell Physiol. 2021;320(1):C119-C131.

Tong L, Zhao Q, Datan E, Lin GQ, Minn I, Pomper MG, Yu B, Romo D, He QL, Liu JO. Triptolide: reflections on two decades of research and prospects for the future. Nat Prod Rep. 2021;38(4):843-860.

Tsai KYF, Tullis B, Breithaupt KL, Fowers R, Jones N, Grajeda S, Reynolds PR, Arroyo JA. A Role for RAGE in DNA Double Strand Breaks (DSBs) Detected in Pathological Placentas and Trophoblast Cells. Cells. 2021;10(4).

Wang X, Rojas-Quintero J, Zhang D, Nakajima T, Walker KH, Peh HY, Li Y, Fucci QA, Tesfaigzi Y, Owen CA. A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice. Mucosal Immunol. 2021;14(2):342-356.

Wang X, Zhang D, Fucci QA, Dollery CM, Owen CA. Surface-bound matrix metalloproteinase-8 on macrophages: Contributions to macrophage pericellular proteolysis and migration through tissue barriers. Physiol Rep. 2021;9(5):e14778.

Zafari Z, Li S, Eakin MN, Bellanger M, Reed RM. Projecting Long-term Health and Economic Burden of COPD in the United States. Chest. 2021;159(4):1400-1410.

Presentations and Abstracts 2021

Numata-Nakamura M, Bochkov YA, Lee H, Seibold MA, Voelker  DR.  Pulmonary surfactant phospholipids inhibit human rhinovirus C infection and replication in human airway epithelial cells [abs]. Am J Respir Crit Care Med 2021;203:A4165.

Rosen L, Zucker D, Guttmam N, Brown N, Bitan M, Rule A, Berkovitch M, Myers V.  An intervention to protect children from tobacco smoke exposure.  Presented at the SRNT 27th Annual Meeting (entirely virtual). Feb 24-27, 2021.

Vivas G, Florez M, Colussi D, Barrero CA. Effect of cigarette smoke on cytokine production in human macrophages. Presented at Temple University School of Pharmacy Research Recognition Day. Philadelphia, PA, Apr 2021.

Book Chapters, etc., 2021

Meyers, D. Invention Disclosure. Inhibitors of human cytomegalovirus; JHU reference C16649. 2021.